Profiles
Dr Zoe Brookes
Associate Professor of Dental Education and Research
Peninsula Dental School (Faculty of Health)
Biography
Biography
Associate Head of School - Teaching and Learning Associate Professor in Dental Education and Research
Clinical Lead of Oral Microbiome Research Group
Zoe is currently employed at the University of Plymouth as the Associate Head of School for Teaching and Learning, and as an Associate Professor in Dental Education and Research. This involves undertaking a variety of educational roles, including overseeing Years 1-5 of the BDS Programme curriculum (Bachelor of Dental Surgery) and Years 1-3 of the DTH curriculum (Dental Hygiene and Therapy), Applied Dental Knowledge assessment lead, Enquiry Based Learning lead and Intercalating MSc Dental lead. These roles fulfil an interest in integrated healthcare models, applied and experiential learning, and Zoe helps to support early career researchers nationally through her role as Treasurer for the British Society of Oral and Dental Research. Zoe takes pride in leading the Peninsula Dental School 2023 curriculum that was ranked first place in the Guardian League table for teaching quality, third in the National Student Survey for student satisfaction, winner of the Times Higher Education Award for Community Dentistry. The University of Plymouth was also recently awarded a TEF Gold and the Faculty a Athena Swan Silver Award.
In 2018 Zoe first established and led the this Plymouth Oral Microbiome Research Group alongside Dr Raul Bescos. Zoe’s current research interests involve undertaking clinical research in a primary care dental setting, that directly benefit the oral and general health of patients, having developed industrial partnerships with Oralieve and Haleon to support these studies. The team undertake studies specifically investigating the mechanisms linking oral health and systemic disease, with a focus on cardiovascular disease and mouthwash use.
Zoe also leads blood pressure case finding clinics with Peninsula Dental Social Enterprise, which include investigating links between the oral microbiome and hypertension, pre-eclampsia and menopause, as well as the effects of antimicrobial mouthwashes on the oral microbiome. Publications in this field have led to leadership of the FDI task team on global recommendations for mouthwash use, and coining the term ‘balancing the oral microbiome’ for best practice.
Before graduating to be Dentist from Peninsula Dental School (as one of the first cohorts in this pioneering new school), Zoe originally graduated with a BSc in Physiology and Pharmacology. This was followed by a PhD from the University of Sheffield, completed in 2000, which investigated the effects of anaesthetics on the microcirculation. In 2000-2002, Zoe then worked at the University of Alberta, Canada, Department of Physiology, as a Postdoctoral Research Fellow, being grant funded by the National Institute for Health and Care Research, but returned to Sheffield as a Non-Clinical Lecturer and Principal Investigator between 2002-2010. Here, Zoe published in the field of sepsis, was Assistant Editor of the British Journal of Anaesthesia, and pioneered the early use of statins, with research identifying new drugs that improved blood flow and reduced inflammation during sepsis.
Since graduating in dentistry from Plymouth University in 2014, Zoe has practised for 10 years as a general dentist for the NHS in Plymouth, with an interest in anxious patients and periodontal disease. This has now led to work in a community health care setting as a PDSE dentist, fulfilling ambitions to work as a health care provider serving those most at need of urgent restorative, surgical and periodontal treatment.
Qualifications
PhD, PCHE, SFHEA, MJDF (RCS, Eng), BDS, BSc (Hons)
2021 - present: Associate Professor, BDS Year 2 Programme Lead, Peninsula Dental School, Faculty of Medicine and Dentistry, University of Plymouth, UK (0.8FTE)
2016 - 2021 Clinical Lecturer
2015 - present: General Dentist, Plymouth, UK (0.2FTE)
2009 - 2010: Honorary Lecturer, Department of Cardiovascular Sciences, University of Sheffield, UK
2002 - 2009: Lecturer/Principal Investigator for Microcirculation, Sepsis and Anaesthesia Research Group, University of Sheffield, UK
2000 - 2002: Postdoctoral Fellow (NIHR/CIHR), Department of Physiology, HMRC, University of Alberta, Canada
1999 - 2000: Postdoctoral Research Associate, Department of Surgical and Anaesthetic Sciences, University of Sheffield, UK
Education
2014 - 2015: DF1 training, Plymouth Scheme
2010 - 2014: BDS Peninsula School of Medicine and Dentistry, Universites of Plymouth and Exeter, UK
1995 - 1999: PhD Effects of intravenous anaesthesia on the microcirculation in vivo. University of Sheffield, UK
1996 - 1998: Postgraduate Certificate in Higher Education, University of Sheffield, UK
1992 - 1995: BSc Hons Physiology and Pharmacology, University of Sheffield, UK
2021 - present: Associate Professor, BDS Year 2 Programme Lead, Peninsula Dental School, Faculty of Medicine and Dentistry, University of Plymouth, UK (0.8FTE)
2016 - 2021 Clinical Lecturer
2015 - present: General Dentist, Plymouth, UK (0.2FTE)
2009 - 2010: Honorary Lecturer, Department of Cardiovascular Sciences, University of Sheffield, UK
2002 - 2009: Lecturer/Principal Investigator for Microcirculation, Sepsis and Anaesthesia Research Group, University of Sheffield, UK
2000 - 2002: Postdoctoral Fellow (NIHR/CIHR), Department of Physiology, HMRC, University of Alberta, Canada
1999 - 2000: Postdoctoral Research Associate, Department of Surgical and Anaesthetic Sciences, University of Sheffield, UK
Education
2014 - 2015: DF1 training, Plymouth Scheme
2010 - 2014: BDS Peninsula School of Medicine and Dentistry, Universites of Plymouth and Exeter, UK
1995 - 1999: PhD Effects of intravenous anaesthesia on the microcirculation in vivo. University of Sheffield, UK
1996 - 1998: Postgraduate Certificate in Higher Education, University of Sheffield, UK
1992 - 1995: BSc Hons Physiology and Pharmacology, University of Sheffield, UK
Professional membership
GDC 252112
Senior Fellow of Advance HE (SFHEA)
Membership of the Faculty of Dental Surgery (Royal College of Surgeons, England)
British Dental Association
International Association for Dental Research / British Society Oral and Dental Research
British Vascular Biology and Microcirculation Society
Senior Fellow of Advance HE (SFHEA)
Membership of the Faculty of Dental Surgery (Royal College of Surgeons, England)
British Dental Association
International Association for Dental Research / British Society Oral and Dental Research
British Vascular Biology and Microcirculation Society
Roles on external bodies
Lead for the FDI International task team for mouthwashes in oral care https://www.fdiworlddental.org/task-teams
Assistant Treasurer and committee member, British Society Oral and Dental Research
CDO CVD advisory board committee member
External Programme Examiner for BMedSci (intercalated research degree), School of Medicine, University of Sheffield
CRN NIHR Oral and Dental sub Specialty Lead, South West and Wales
CRN Primary Care Dental Champion, South West and Wales
BHF grant reviewer
CDO CVD advisory board committee member
External Programme Examiner for BMedSci (intercalated research degree), School of Medicine, University of Sheffield
CRN NIHR Oral and Dental sub Specialty Lead, South West and Wales
CRN Primary Care Dental Champion, South West and Wales
BHF grant reviewer
Teaching
Teaching
Teaching interests
Undergraduate small and large group teaching, plenaries and curriculum design for BDS and BSc DTH courses
Postgraduate teaching and supervision, including PhD students, in areas of research interest and expertise
Interested in research relating to inter-professional education and enquiry based learning (EBL)
Areas of interest for teaching: cardiovascular physiology and pharmacology, systemic inflammatory diseases, oral microbiology and immunology
Postgraduate teaching and supervision, including PhD students, in areas of research interest and expertise
Interested in research relating to inter-professional education and enquiry based learning (EBL)
Areas of interest for teaching: cardiovascular physiology and pharmacology, systemic inflammatory diseases, oral microbiology and immunology
Research
Research
Research interests
Plymouth Oral Microbiome research Group (Bescos, Brookes): effects of oral health systemic disease, focussing on the oral microbiomehttps://www.plymouth.ac.uk/research/biomedical-research-group/oral-microbiome-research-group
See latest publication invesitigating the effects of chlorhexidine mouthwash on the oral microbiome
https://www.nature.com/articles/s41598-020-61912-4
Effects of sepsis on endothelial cells and the microcirculation
See latest publication invesitigating the effects of chlorhexidine mouthwash on the oral microbiome
https://www.nature.com/articles/s41598-020-61912-4
Effects of sepsis on endothelial cells and the microcirculation
Publications
Publications
Key publications
Key publications are highlighted
Journals
Doble A, Bescos R, Witton R, Shivji S, Ayres R,
Brookes Z. A Case-Finding Protocol
for High Cardiovascular Risk in a Primary Care Dental School-Model with
Integrated Care. Int J Environ Res Public Health. 2023;20(6):4959.
Ali K, Alhaija ESA, Raja M, Zahra D, Brookes ZL, McColl E, Zafar S, Kirnbauer B, Al Wahadni AM, Al-Fodeh RS, Bani-Hani TG, Daher SO, Daher HO. Blended learning in undergraduate dental education: a global pilot study. Med Educ Online. 2023 Dec;28(1):2171700.
Roy H, Bescos R, McColl E, Rehman U, Cray E, Belfield LA, Nweze KD, Tsang K, Singleton W, Whitfield P, Brookes Z. Oral microbes and the formation of cerebral abscesses: A single-centre retrospective study. J Dent. 2023 Jan;128:104366.
Brookes Z, Mills I, Witton R, McColl E Top tips for incorporating research Br Dent J. 2022;232(7):427-429.
Ali K, Gupta P, Turay E, Burns L, Brookes Z, Raja M. Dentistry in a multicultural society: the impact of animal-based products on person-centred care. Br Dent J. 2022;232(4):269-272.
Ali K, Venkatasami N, Zahra D, Brookes Z, Kisielewska J. Evaluation of sepsis teaching for medical and dental students at a British University. Eur J Dent Educ. 2021 Jun 15. doi: 10.1111/eje.12702.
Brookes ZLS, Bescos R, Belfield LA, Ali K, Roberts A. Current uses of chlorhexidine for management of oral disease: a narrative review. J Dent. 2020;103:103497. doi: 10.1016/j.jdent.2020.103497
Bescos, R., Ashworth, A., Cutler, C., Brookes, Z. L.,Belfield, L., Rodiles, A., . . . Hickson, M. (2020). Effects of Chlorhexidine mouthwash on the oral microbiome. Scientific Reports, 10(1). doi:10.1038/s41598-020-61912-4
Bescos R, Brookes Z, Belfield L, Fenandez-Sanjuro M, Casas-Agustench P. Modulation of oral microbiota: A new frontier in exercise supplementation. PharmaNutrition14 2020: 100230.
Bescos, R., Casas-Agustench, P., Belfield, L., Brookes, Z., & Gabaldón, T. (2020). Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. Journal of Dental Research, 002203452093214. doi:10.1177/0022034520932149
Zahra, D., Bennett, J., Belfield, L., Ali, K., McIlwaine, C., Bruce, M., . . . Zaric, S. (2019). Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum. European Journal of Dental Education. doi:10.1111/eje.12451
McIlwaine, C., Brookes, Z. L. S., Zahra, D., Ali, K., Zaric, S., Jones, G., & Belfield, L. A. (2019). A novel, integrated curriculum for dental hygiene-therapists and dentists. British Dental Journal, 226, 67. Retrieved from https://doi.org/10.1038/sj.bdj.2019.10
McGown, C. C., Brookes, Z. L. S., Hellewell, P. G., Ross, J. J., & Brown, N. J. (2015). Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII. Naunyn-Schmiedeberg's Archives of Pharmacology, 388(5), 557-564. doi:10.1007/s00210-015-1100-y
Alfieri, A., Ong, A. C. M., Kammerer, R. A., Solanky, T., Bate, S., Tasab, M., . . . Brookes, Z. L. (2014). Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin. Pharmacological Research, 80, 43-51. doi:10.1016/j.phrs.2013.12.008
Brookes, Z. L. S., Stedman, E. N., Brown, N. J., Hebbes, C. P., Guerrini, R., Calo, G., . . . Lambert, D. G. (2013). The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo. PLoS ONE, 8(9), e74943. doi:10.1371/journal.pone.0074943
Brookes, Z. L. S., Ruff, L., Upadhyay, V. S., Huang, L., Prasad, S., Solanky, T., . . . Ong, A. C. M. (2013). Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. American Journal of Physiology-Heart and Circulatory Physiology, 304(1), H33-H41. doi:10.1152/ajpheart.01102.2011
Brookes, Z. L. S. (2013). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 14(1), 27-31. doi:10.1016/j.mpaic.2012.11.002
Lawton, B. K., Brown, N. J., Reilly, C. S., & Brookes, Z. L. S. (2012). Role of L-type calcium channels in altered microvascular responses to propofol in hypertension. British Journal of Anaesthesia, 108(6), 929-935. doi:10.1093/bja/aes069
Reeves, K. J., Brookes, Z. L. S., Reed, M. W. R., & Brown, N. J. (2012). Evaluation of Fluorescent Plasma Markers for in vivo Microscopy of the Microcirculation. Journal of Vascular Research, 49(2), 132-143. doi:10.1159/000331281
Alfieri, A., Watson, J. J., Kammerer, R. A., Tasab, M., Progias, P., Reeves, K., . . . Brookes, Z. L. (2012). Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Critical Care, 16(5), R182. doi:10.1186/cc11666
McGown, C. C., Brown, N. J., Hellewell, P. G., & Brookes, Z. L. S. (2011). ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. Microvascular Research, 81(3), 281-288. doi:10.1016/j.mvr.2011.02.003
Debono, M., Sheppard, L., Irving, S., Jackson, P., Butterworth, J., Brookes, Z. L. S., . . . Ross, R. J. (2011). Assessing adrenal status in patients before and immediately after coronary artery bypass graft surgery. European Journal of Endocrinology, 164(3), 413-419. doi:10.1530/eje-10-0996
Mansart, A., Ruff, L. J., Ariaans, M. P., Ross, J. J., Reilly, C. S., Brown, N. J., . . . Brookes, Z. L. S. (2010). Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(6), 555-562. doi:10.1007/s00210-010-0514-9
Brookes, Z. L. S. (2010). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 11(2), 78-82. doi:10.1016/j.mpaic.2009.10.018
McGown, C. C., Brown, N. J., Hellewell, P. G., Reilly, C. S., & Brookes, Z. L. S. (2010). Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III. British Journal of Anaesthesia, 104(2), 183-190. doi:10.1093/bja/aep361
Scicluna, J. K., Mansart, A., Ross, J. J., Reilly, C. S., Brown, N. J., & Brookes, Z. L. S. (2009). Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects. European Journal of Pharmacology, 621(1-3), 67-70. doi:10.1016/j.ejphar.2009.08.029
Brookes, Z. L. S., Mansart, A., McGown, C. C., Ross, J. J., Reilly, C. S., & Brown, N. J. (2009). Macromolecular Leak from Extrasplenic Lymphatics during Endotoxemia. Lymphatic Research and Biology, 7(3), 131-137. doi:10.1089/lrb.2008.1019
Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073
Brookes, Z. L. S., McGown, C. C., & Reilly, C. S. (2009). Statins for all: the new premed?. British Journal of Anaesthesia, 103(1), 99-107. doi:10.1093/bja/aep149
Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Lipopolysaccahride abolishes extra-splenic vasoconstriction to atrial natriuretic peptide: the role of nitric oxide and endothelin-1. Shock2008; 29(6):675-80. 10.1097/shk.0b013e31815811a3
Scicluna J, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Diminished contraction of rat peripheral arteries to phenylephrine,during exposure to lipopolysaccharide in vitro, involves nitric oxide and endothelin-1. Shock 2008; 29(3):417-21.10.1097/shk.0b013e318142c5df
Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009.). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073
Brookes, Z. L. S., Stedman, E. N., Guerrini, R., Lawton, B. K., Calo, G., & Lambert, D. G. (2007). Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine. American Journal of Physiology-Heart and Circulatory Physiology, 293(5), H2977-H2985. doi:10.1152/ajpheart.00448.2007
McGown, C. C., & Brookes, Z. L. S. (2007). Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. British Journal of Anaesthesia, 98(2), 163-175. doi:10.1093/bja/ael358
Brookes, Z. L. S., Reilly, C. S., Lawton, B. K., & Brown, N. J. (2006). Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of cd11b after hemorrhage. Shock, 25(5), 492-499. doi:10.1097/01.shk.0000209541.76305.8e
Li, Y., Brookes, Z. L. S., & Kaufman, S. (2005). Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature. Regulatory Peptides, 132(1-3), 41-46. doi:10.1016/j.regpep.2005.09.009
Hall, E., & Brookes, Z. L. S. (2005). Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Regulatory Peptides, 131(1-3), 34-37. doi:10.1016/j.regpep.2005.06.006
Dhawan, V., Brookes, Z. L. S., & Kaufman, S. (2005). Repeated pregnancies (multiparity) increases venous tone and reduces compliance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289(1), R23-R28. doi:10.1152/ajpregu.00034.2005
Brookes, Z. L. S., & Kaufman, S. (2005). Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo. The Journal of Physiology, 565(1), 269-277. doi:10.1113/jphysiol.2005.083147
Dhawan, V., Brookes, Z., & Kaufman, S. (2004). Long-term effects of repeated pregnancies (multiparity) on blood pressure regulation. Cardiovascular Research, 64(1), 179-186. doi:10.1016/j.cardiores.2004.06.018
Brookes, Z. L., Reilly, C. S., & Brown, N. J. (2004). Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo. British Journal of Anaesthesia, 93(2), 249-256. doi:10.1093/bja/aeh190
Brookes, Z. L. S., & Kaufman, S. (2003). Myogenic responses and compliance of mesenteric and splenic vasculature in the rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284(6), R1604-R1610. doi:10.1152/ajpregu.00411.2002
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2003). The Dose-Dependent Effects of Fentanyl on Rat Skeletal Muscle Microcirculation In Vivo. Anesthesia & Analgesia, 96(2), 456-462. doi:10.1097/00000539-200302000-00030
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Response of the Rat Cremaster Microcirculation to Hemorrhage In Vivo: Differential Effects of Intravenous Anesthetic Agents. Shock, 18(6), 542-548. doi:10.1097/00024382-200212000-00010
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage. British Journal of Anaesthesia, 88(2), 255-263. doi:10.1093/bja/88.2.255
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2000). Intravenous anaesthesia and the rat microcirculation: the Dorsal Microcirculatory Chamber. British Journal of Anaesthesia, 85(6), 901-903. doi:10.1093/bja/85.6.901
Ali K, Alhaija ESA, Raja M, Zahra D, Brookes ZL, McColl E, Zafar S, Kirnbauer B, Al Wahadni AM, Al-Fodeh RS, Bani-Hani TG, Daher SO, Daher HO. Blended learning in undergraduate dental education: a global pilot study. Med Educ Online. 2023 Dec;28(1):2171700.
Roy H, Bescos R, McColl E, Rehman U, Cray E, Belfield LA, Nweze KD, Tsang K, Singleton W, Whitfield P, Brookes Z. Oral microbes and the formation of cerebral abscesses: A single-centre retrospective study. J Dent. 2023 Jan;128:104366.
Brookes Z, Mills I, Witton R, McColl E Top tips for incorporating research Br Dent J. 2022;232(7):427-429.
Ali K, Gupta P, Turay E, Burns L, Brookes Z, Raja M. Dentistry in a multicultural society: the impact of animal-based products on person-centred care. Br Dent J. 2022;232(4):269-272.
Ali K, Venkatasami N, Zahra D, Brookes Z, Kisielewska J. Evaluation of sepsis teaching for medical and dental students at a British University. Eur J Dent Educ. 2021 Jun 15. doi: 10.1111/eje.12702.
Brookes ZLS, Bescos R, Belfield LA, Ali K, Roberts A. Current uses of chlorhexidine for management of oral disease: a narrative review. J Dent. 2020;103:103497. doi: 10.1016/j.jdent.2020.103497
Bescos, R., Ashworth, A., Cutler, C., Brookes, Z. L.,Belfield, L., Rodiles, A., . . . Hickson, M. (2020). Effects of Chlorhexidine mouthwash on the oral microbiome. Scientific Reports, 10(1). doi:10.1038/s41598-020-61912-4
Bescos R, Brookes Z, Belfield L, Fenandez-Sanjuro M, Casas-Agustench P. Modulation of oral microbiota: A new frontier in exercise supplementation. PharmaNutrition14 2020: 100230.
Bescos, R., Casas-Agustench, P., Belfield, L., Brookes, Z., & Gabaldón, T. (2020). Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. Journal of Dental Research, 002203452093214. doi:10.1177/0022034520932149
Zahra, D., Bennett, J., Belfield, L., Ali, K., McIlwaine, C., Bruce, M., . . . Zaric, S. (2019). Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum. European Journal of Dental Education. doi:10.1111/eje.12451
McIlwaine, C., Brookes, Z. L. S., Zahra, D., Ali, K., Zaric, S., Jones, G., & Belfield, L. A. (2019). A novel, integrated curriculum for dental hygiene-therapists and dentists. British Dental Journal, 226, 67. Retrieved from https://doi.org/10.1038/sj.bdj.2019.10
McGown, C. C., Brookes, Z. L. S., Hellewell, P. G., Ross, J. J., & Brown, N. J. (2015). Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII. Naunyn-Schmiedeberg's Archives of Pharmacology, 388(5), 557-564. doi:10.1007/s00210-015-1100-y
Alfieri, A., Ong, A. C. M., Kammerer, R. A., Solanky, T., Bate, S., Tasab, M., . . . Brookes, Z. L. (2014). Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin. Pharmacological Research, 80, 43-51. doi:10.1016/j.phrs.2013.12.008
Brookes, Z. L. S., Stedman, E. N., Brown, N. J., Hebbes, C. P., Guerrini, R., Calo, G., . . . Lambert, D. G. (2013). The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo. PLoS ONE, 8(9), e74943. doi:10.1371/journal.pone.0074943
Brookes, Z. L. S., Ruff, L., Upadhyay, V. S., Huang, L., Prasad, S., Solanky, T., . . . Ong, A. C. M. (2013). Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone. American Journal of Physiology-Heart and Circulatory Physiology, 304(1), H33-H41. doi:10.1152/ajpheart.01102.2011
Brookes, Z. L. S. (2013). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 14(1), 27-31. doi:10.1016/j.mpaic.2012.11.002
Lawton, B. K., Brown, N. J., Reilly, C. S., & Brookes, Z. L. S. (2012). Role of L-type calcium channels in altered microvascular responses to propofol in hypertension. British Journal of Anaesthesia, 108(6), 929-935. doi:10.1093/bja/aes069
Reeves, K. J., Brookes, Z. L. S., Reed, M. W. R., & Brown, N. J. (2012). Evaluation of Fluorescent Plasma Markers for in vivo Microscopy of the Microcirculation. Journal of Vascular Research, 49(2), 132-143. doi:10.1159/000331281
Alfieri, A., Watson, J. J., Kammerer, R. A., Tasab, M., Progias, P., Reeves, K., . . . Brookes, Z. L. (2012). Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis. Critical Care, 16(5), R182. doi:10.1186/cc11666
McGown, C. C., Brown, N. J., Hellewell, P. G., & Brookes, Z. L. S. (2011). ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase. Microvascular Research, 81(3), 281-288. doi:10.1016/j.mvr.2011.02.003
Debono, M., Sheppard, L., Irving, S., Jackson, P., Butterworth, J., Brookes, Z. L. S., . . . Ross, R. J. (2011). Assessing adrenal status in patients before and immediately after coronary artery bypass graft surgery. European Journal of Endocrinology, 164(3), 413-419. doi:10.1530/eje-10-0996
Mansart, A., Ruff, L. J., Ariaans, M. P., Ross, J. J., Reilly, C. S., Brown, N. J., . . . Brookes, Z. L. S. (2010). Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1. Naunyn-Schmiedeberg's Archives of Pharmacology, 381(6), 555-562. doi:10.1007/s00210-010-0514-9
Brookes, Z. L. S. (2010). Pharmacological modulation of cardiac function and blood vessel calibre. Anaesthesia & Intensive Care Medicine, 11(2), 78-82. doi:10.1016/j.mpaic.2009.10.018
McGown, C. C., Brown, N. J., Hellewell, P. G., Reilly, C. S., & Brookes, Z. L. S. (2010). Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III. British Journal of Anaesthesia, 104(2), 183-190. doi:10.1093/bja/aep361
Scicluna, J. K., Mansart, A., Ross, J. J., Reilly, C. S., Brown, N. J., & Brookes, Z. L. S. (2009). Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects. European Journal of Pharmacology, 621(1-3), 67-70. doi:10.1016/j.ejphar.2009.08.029
Brookes, Z. L. S., Mansart, A., McGown, C. C., Ross, J. J., Reilly, C. S., & Brown, N. J. (2009). Macromolecular Leak from Extrasplenic Lymphatics during Endotoxemia. Lymphatic Research and Biology, 7(3), 131-137. doi:10.1089/lrb.2008.1019
Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073
Brookes, Z. L. S., McGown, C. C., & Reilly, C. S. (2009). Statins for all: the new premed?. British Journal of Anaesthesia, 103(1), 99-107. doi:10.1093/bja/aep149
Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Lipopolysaccahride abolishes extra-splenic vasoconstriction to atrial natriuretic peptide: the role of nitric oxide and endothelin-1. Shock2008; 29(6):675-80. 10.1097/shk.0b013e31815811a3
Scicluna J, Mansart A, Ross JJ, Reilly CS, Brown NJ, Brookes ZLS. Diminished contraction of rat peripheral arteries to phenylephrine,during exposure to lipopolysaccharide in vitro, involves nitric oxide and endothelin-1. Shock 2008; 29(3):417-21.10.1097/shk.0b013e318142c5df
Chamberlain, J., Francis, S., Brookes, Z., Shaw, G., Graham, D., Alp, N. J., . . . Crossman, D. C. (2009.). Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding. PLoS ONE, 4(4), e5073. doi:10.1371/journal.pone.0005073
Brookes, Z. L. S., Stedman, E. N., Guerrini, R., Lawton, B. K., Calo, G., & Lambert, D. G. (2007). Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine. American Journal of Physiology-Heart and Circulatory Physiology, 293(5), H2977-H2985. doi:10.1152/ajpheart.00448.2007
McGown, C. C., & Brookes, Z. L. S. (2007). Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide. British Journal of Anaesthesia, 98(2), 163-175. doi:10.1093/bja/ael358
Brookes, Z. L. S., Reilly, C. S., Lawton, B. K., & Brown, N. J. (2006). Intravenous anesthesia inhibits leukocyte-endothelial interactions and expression of cd11b after hemorrhage. Shock, 25(5), 492-499. doi:10.1097/01.shk.0000209541.76305.8e
Li, Y., Brookes, Z. L. S., & Kaufman, S. (2005). Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature. Regulatory Peptides, 132(1-3), 41-46. doi:10.1016/j.regpep.2005.09.009
Hall, E., & Brookes, Z. L. S. (2005). Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis. Regulatory Peptides, 131(1-3), 34-37. doi:10.1016/j.regpep.2005.06.006
Dhawan, V., Brookes, Z. L. S., & Kaufman, S. (2005). Repeated pregnancies (multiparity) increases venous tone and reduces compliance. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 289(1), R23-R28. doi:10.1152/ajpregu.00034.2005
Brookes, Z. L. S., & Kaufman, S. (2005). Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat in vivo. The Journal of Physiology, 565(1), 269-277. doi:10.1113/jphysiol.2005.083147
Dhawan, V., Brookes, Z., & Kaufman, S. (2004). Long-term effects of repeated pregnancies (multiparity) on blood pressure regulation. Cardiovascular Research, 64(1), 179-186. doi:10.1016/j.cardiores.2004.06.018
Brookes, Z. L., Reilly, C. S., & Brown, N. J. (2004). Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo. British Journal of Anaesthesia, 93(2), 249-256. doi:10.1093/bja/aeh190
Brookes, Z. L. S., & Kaufman, S. (2003). Myogenic responses and compliance of mesenteric and splenic vasculature in the rat. American Journal of Physiology-Regulatory, Integrative and Comparative Physiology, 284(6), R1604-R1610. doi:10.1152/ajpregu.00411.2002
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2003). The Dose-Dependent Effects of Fentanyl on Rat Skeletal Muscle Microcirculation In Vivo. Anesthesia & Analgesia, 96(2), 456-462. doi:10.1097/00000539-200302000-00030
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Response of the Rat Cremaster Microcirculation to Hemorrhage In Vivo: Differential Effects of Intravenous Anesthetic Agents. Shock, 18(6), 542-548. doi:10.1097/00024382-200212000-00010
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2002). Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage. British Journal of Anaesthesia, 88(2), 255-263. doi:10.1093/bja/88.2.255
Brookes, Z. L. S., Brown, N. J., & Reilly, C. S. (2000). Intravenous anaesthesia and the rat microcirculation: the Dorsal Microcirculatory Chamber. British Journal of Anaesthesia, 85(6), 901-903. doi:10.1093/bja/85.6.901
Articles
(2024) 'The realities of amalgam teaching' British Dental Journal 236, (3) 147-147 Publisher Site , DOI
(2023) 'Uncontrolled hypertension at the dentist: a case report of integrated healthcare' British Dental Journal 235, (11) 866-868 , DOI Open access
(2023) 'Mouthwashes: Implications for Practice' International Dental Journal 73, (Supplement 2) S98-S101 , DOI Open access
(2023) 'Mouthwashes: Alternatives and Future Directions' International Dental Journal 73, S89-S97 , DOI Open access
(2023) 'Antimicrobial Mouthwashes: An Overview of Mechanisms—What Do We Still Need to Know?' International Dental Journal , DOI Open access
(2023) 'Mouthwash Effects on the Oral Microbiome: Are They Good, Bad, or Balanced?' International Dental Journal 73, (Supplement 2) S74-S81 , DOI Open access
(2023) 'A Case-Finding Protocol for High Cardiovascular Risk in a Primary Care Dental School—Model with Integrated Care' International Journal of Environmental Research and Public Health 20, (6) 4959-4959 , DOI Open access
(2023) 'Blended learning in undergraduate dental education: a global pilot study' Medical Education Online 28, (1) , DOI Open access
(2022) 'Oral microbes and the formation of cerebral abscesses: a single-centre retrospective study' Journal of Dentistry , DOI Open access
(2022) 'Top tips for incorporating research' British Dental Journal 232, (7) 427-429 Publisher Site , DOI Open access
(2022) 'Dentistry in a multicultural society: the impact of animal-based products on person-centred care' British Dental Journal 232, (4) 269-272 , DOI Open access
(2021) 'Effects of chlorhexidine mouthwash on the oral microbiome' Journal of Dentistry 113, Publisher Site , DOI Open access
(2021) 'Evaluation of Sepsis Teaching for Medical and Dental Students at a British University' European Journal of Dental Education , DOI Open access
(2020) 'Current uses of chlorhexidine for management of oral disease: a narrative review' Journal of Dentistry 103, 103497-103497 Publisher Site , DOI Open access
(2020) 'Modulation of oral microbiota: A new frontier in exercise supplementation' PharmaNutrition 14, 100230-100230 , DOI Open access
(2020) 'Effects of Chlorhexidine mouthwash on the oral microbiome' Scientific Reports 10, (1) 0-0 , DOI Open access
(2019) 'Effect of Constant versus Variable Small-Group Facilitators on Student Basic Science Knowledge in an Enquiry-Based Dental Curriculum' European Journal of Dental Education 0, (ja) , DOI Open access
(2019) 'A novel, integrated curriculum for dental hygiene-therapists and dentists' British Dental Journal 226, 67-67 Open access
(2015) 'Atorvastatin reduces endotoxin-induced microvascular inflammation via NOSII' Naunyn-Schmiedeberg's Archives of Pharmacology 388, (5) 557-564 Publisher Site , DOI
(2014) 'Angiopoietin-1 regulates microvascular reactivity and protects the microcirculation during acute endothelial dysfunction: Role of eNOS and VE-cadherin' Pharmacological Research 80, 43-51 Publisher Site , DOI
(2013) 'The Nociceptin/Orphanin FQ Receptor Antagonist UFP-101 Reduces Microvascular Inflammation to Lipopolysaccharide In Vivo' PLoS ONE 8, (9) e74943-e74943 Publisher Site , DOI
(2013) 'Pharmacological modulation of cardiac function and blood vessel calibre' Anaesthesia & Intensive Care Medicine 14, (1) 27-31 Publisher Site , DOI
(2012) 'Pkd2 mesenteric vessels exhibit a primary defect in endothelium-dependent vasodilatation restored by rosiglitazone' American Journal of Physiology-Heart and Circulatory Physiology 304, (1) H33-H41 Publisher Site , DOI
(2012) 'Role of L-type calcium channels in altered microvascular responses to propofol in hypertension' British Journal of Anaesthesia 108, (6) 929-935 Publisher Site , DOI
(2012) 'Angiopoietin-1 variant reduces LPS-induced microvascular dysfunction in a murine model of sepsis' Critical Care 16, (5) R182-R182 Publisher Site , DOI
(2012) 'Evaluation of Fluorescent Plasma Markers for in vivo Microscopy of the Microcirculation' Journal of Vascular Research 49, (2) 132-143 Publisher Site , DOI
(2011) 'ROCK induced inflammation of the microcirculation during endotoxemia mediated by nitric oxide synthase' Microvascular Research 81, (3) 281-288 Publisher Site , DOI
(2010) 'Assessing adrenal status in patients before and immediately after coronary artery bypass graft surgery' European Journal of Endocrinology 164, (3) 413-419 Publisher Site , DOI
(2010) 'The effects of haemorrhage on the microcirculation during intravenous anaesthesia'
(2010) 'Constriction of rat extra-splenic veins to lipopolysaccharide involves endothelin-1' Naunyn-Schmiedeberg's Archives of Pharmacology 381, (6) 555-562 Publisher Site , DOI
(2010) 'Beneficial microvascular and anti-inflammatory effects of pravastatin during sepsis involve nitric oxide synthase III' British Journal of Anaesthesia 104, (2) 183-190 Publisher Site , DOI
(2010) 'Pharmacological modulation of cardiac function and blood vessel calibre' Anaesthesia & Intensive Care Medicine 11, (2) 78-82 Publisher Site , DOI
(2009) 'Lipopolysaccharide alters vasodilation to atrial natriuretic peptide via nitric oxide and endothelin-1: Time-dependent effects' European Journal of Pharmacology 621, (1-3) 67-70 Publisher Site , DOI
(2009) 'Macromolecular Leak from Extrasplenic Lymphatics during Endotoxemia' Lymphatic Research and Biology 7, (3) 131-137 Publisher Site , DOI
(2009) 'Statins for all: the new premed?' British Journal of Anaesthesia 103, (1) 99-107 Publisher Site , DOI
(2009) 'Interleukin-1 Regulates Multiple Atherogenic Mechanisms in Response to Fat Feeding' PLoS ONE 4, (4) e5073-e5073 Publisher Site , DOI
(2008) 'LPS ABOLISHES EXTRASPLENIC VASOCONSTRICTION TO ATRIAL NATRIURETIC PEPTIDE' Shock 29, (6) 675-680 Publisher Site , DOI
(2008) 'REDUCED VASCULAR RESPONSE TO PHENYLEPHRINE DURING EXPOSURE TO LIPOPOLYSACCHARIDE IN VITRO INVOLVES NITRIC OXIDE AND ENDOTHELIN 1' Shock 29, (3) 417-421 Publisher Site , DOI
(2007) 'Proinflammatory and vasodilator effects of nociceptin/orphanin FQ in the rat mesenteric microcirculation are mediated by histamine' American Journal of Physiology-Heart and Circulatory Physiology 293, (5) H2977-H2985 Publisher Site , DOI
(2007) 'Beneficial effects of statins on the microcirculation during sepsis: the role of nitric oxide' British Journal of Anaesthesia 98, (2) 163-175 Publisher Site , DOI
(2006) 'INTRAVENOUS ANESTHESIA INHIBITS LEUKOCYTE-ENDOTHELIAL INTERACTIONS AND EXPRESSION OF CD11B AFTER HEMORRHAGE' Shock 25, (5) 492-499 Publisher Site , DOI
(2005) 'Angiopoietin-1 increases arteriolar vasoconstriction to phenylephrine during sepsis' Regulatory Peptides 131, (1-3) 34-37 Publisher Site , DOI
(2005) 'Acute and chronic effects of relaxin on vasoactivity, myogenic reactivity and compliance of the rat mesenteric arterial and venous vasculature' Regulatory Peptides 132, (1-3) 41-46 Publisher Site , DOI
(2005) 'Repeated pregnancies (multiparity) increases venous tone and reduces compliance' American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 289, (1) R23-R28 Publisher Site , DOI
(2005) 'Effects of atrial natriuretic peptide on the extrasplenic microvasculature and lymphatics in the rat <i>in vivo</i>' The Journal of Physiology 565, (1) 269-277 Publisher Site , DOI
(2004) 'Long-term effects of repeated pregnancies (multiparity) on blood pressure regulation' Cardiovascular Research 64, (1) 179-186 Publisher Site , DOI
(2004) 'Differential effects of propofol, ketamine, and thiopental anaesthesia on the skeletal muscle microcirculation of normotensive and hypertensive rats in vivo' British Journal of Anaesthesia 93, (2) 249-256 Publisher Site , DOI
(2003) 'Myogenic responses and compliance of mesenteric and splenic vasculature in the rat' American Journal of Physiology-Regulatory, Integrative and Comparative Physiology 284, (6) R1604-R1610 Publisher Site , DOI
(2003) 'The Dose-Dependent Effects of Fentanyl on Rat Skeletal Muscle Microcirculation In Vivo' Anesthesia & Analgesia 96, (2) 456-462 Publisher Site , DOI
(2002) 'Response of the Rat Cremaster Microcirculation to Hemorrhage In Vivo: Differential Effects of Intravenous Anesthetic Agents' Shock 18, (6) 542-548 Publisher Site , DOI
(2002) 'Differential effects of intravenous anaesthetic agents on the response of rat mesenteric microcirculation in vivo after haemorrhage' British Journal of Anaesthesia 88, (2) 255-263 Publisher Site , DOI
(2000) 'Intravenous anaesthesia and the rat microcirculation: the Dorsal Microcirculatory Chamber †' British Journal of Anaesthesia 85, (6) 901-903 Publisher Site , DOI
Chapters
Brookes ZL (2015). Pharmacological modulation of blood vessel calibre: Basic and advanced sciences for anaesthetic practice: prepare for the FRCA: Key articles from the Medicine and Intensive Care Journal. Elsevier, Ed. Nicholas Page
Conference Papers
(1998) 'Effects of controlled haemorrhage on the microcirculation during ketamine anaesthesia'
Other Publications
(2020) Coronavirus Disease 2019 (COVID-19): Emerging and Future Challenges for Dental and Oral Medicine. SAGE Publications Publisher Site , DOI Open access