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Profiles
Dr Ellie Edlmann
Associate Professor in Neurosurgery and Consultant Neurosurgeon
Peninsula Medical School (Faculty of Health)
Dr Ellie Edlmann can be contacted through arrangement with our Press Office, to speak to the media on these areas of expertise.
- Neuroscience
- Ageing
- Clinical trials
- Delphi method
- Randomised controlled trials
Email publicrelations@plymouth.ac.uk to enquire.
Biography
Biography
I am a consultant neurosurgeon and associate professor working in neurosurgery. I spend 50% of my time in clinical neurosurgery at University Hospitals Plymouth NHS Trust, with a special interest in brain tumours, traumatic brain injuries and general neurosurgery including spine surgery. The other 50% of my time is focused on research in neurosurgical patients, designing and delivering clinical trials, and research focused on outcomes in older people and traumatic injuries.
My clinical trials experience includes leading on the national Dex-CSDH clinical trial in Chronic Subdural Haematoma, being a co-applicant on the DENS trial for older people with neck fractures and helping design and co-lead the RESTART-tICH trial, randomising timing of recommencement of blood thinners (DOACs) after a traumatic intracranial haemorrhage. I am also a co-applicant on a large national multi-specialty trial assessing surgical site infections (ROSSINI-Platform trial).
I continue to conduct research in the field of Chronic Subdural Haematoma including development of a core outcome set, qualitative research on patient pathways and recovery and am part of a national working group developing guidelines in this area (ICENI).
I continue to conduct research in the field of Chronic Subdural Haematoma including development of a core outcome set, qualitative research on patient pathways and recovery and am part of a national working group developing guidelines in this area (ICENI).
I also have a passion for brain tumour research, working closely with local oncologists, neurologists and psychologists on optimising care in the patient pathway and am working towards future studies and trials in this field, including collaborating with other UK brain tumour leaders and centres.
Qualifications
2024: Awarded CCT in Neurosurgery
2023: Awarded FRCS Neurosurgery, Royal College of Surgeons of England
2019 -24: Clinical lecturer in Neurosurgery, University of Plymouth
2017: Awarded AFHEA (Associate Fellow of the Higher Education Academy)
2015-18: Clinical Neurosciences PhD & neurosurgery research fellow, Wolfson College, University of Cambridge
2011: Started national training in Neurosurgery, South West Peninsula
2010: Awarded MRCS, Royal college of Surgeons of England
2008 - 10: Foundation training, South Thames, London, UK
2008: Bachelor of Medicine, Bachelor of Surgery (BM BS) with honours, Brighton and Sussex Medical School, Brighton, UK
2017: Awarded AFHEA (Associate Fellow of the Higher Education Academy)
2015-18: Clinical Neurosciences PhD & neurosurgery research fellow, Wolfson College, University of Cambridge
2011: Started national training in Neurosurgery, South West Peninsula
2010: Awarded MRCS, Royal college of Surgeons of England
2008 - 10: Foundation training, South Thames, London, UK
2008: Bachelor of Medicine, Bachelor of Surgery (BM BS) with honours, Brighton and Sussex Medical School, Brighton, UK
Professional membership
- Royal College of Surgeons of England (RCS)
- Society of British Neurological Surgeons (SBNS)
- European Association of Neurosurgical Societies (EANS)
- Associate Fellow of the Higher Education Academy (AFHEA)
Roles on external bodies
I am a founding member and co-chair of the International Collaborative Research Initiative on Chronic Subdural Haematoma (iCoRIC) study group; www.icoric.org and am part of the Elderly neurosurgery task force at the European Association of Neurological Societies (EANS).
I have been the national associate sub-specialty lead for clinical trials in neurosurgery, Royal College of Surgeons, which involved helping to support and promote academic activity and clinical trials throughout neurosurgery in the UK. Previously I have been the trainee representative on the specialty advisory committee (SAC) for Neurosurgery and chair of the British Neurosurgical Trainees Research Collaborative (BNTRC).
I have been the national associate sub-specialty lead for clinical trials in neurosurgery, Royal College of Surgeons, which involved helping to support and promote academic activity and clinical trials throughout neurosurgery in the UK. Previously I have been the trainee representative on the specialty advisory committee (SAC) for Neurosurgery and chair of the British Neurosurgical Trainees Research Collaborative (BNTRC).
Key publications
(2021) 'Pathogenesis of Chronic Subdural Hematoma: A Cohort Evidencing De Novo and Transformational Origins' Journal of Neurotrauma 38, (18) 2580-2589 Publisher Site , DOI Open access
(2020) 'Trial of Dexamethasone for Chronic Subdural Hematoma' New England Journal of Medicine 383, (27) 2616-2627 Publisher Site , DOI Open access
Teaching
Teaching
Teaching interests
I am interested in teaching medical students, junior doctors and allied health professionals on any areas relating to neurosurgery, neuroanatomy or research in this field. I am also a mentor for academic trainees and students interested in a career in neurosurgery and support projects and publications.
Research
Research
Research interests
My main research interests have been in clinical trials, head injury and neurosurgery in older patients. During my PhD I worked on the national Dex-CSDH trial which recruited 750 patients to a randomised study on dexamethasone versus placebo to treat chronic subdural haematoma. I have continued this interest in looking at the role of anti-thrombotic medications in head injury. I have also helped establish an international collaborative research initiative on chronic subdural haematoma (iCORIC) which meets annually and shares research ideas, methodology and is planning future studies. I am also a member of the trial steering committee for the establishment of a cranioplasty registry and am interested in the long term outcomes of patients following head injury and cranial reconstruction.
I also conduct research in a wide range of neurosurgical conditions in collaboration with other researchers and students and am always looking for new areas to become involved in.
I also conduct research in a wide range of neurosurgical conditions in collaboration with other researchers and students and am always looking for new areas to become involved in.
Publications
Publications
Key publications
(2021) 'Pathogenesis of Chronic Subdural Hematoma: A Cohort Evidencing De Novo and Transformational Origins' Journal of Neurotrauma 38, (18) 2580-2589 Publisher Site , DOI Open access
(2020) 'Trial of Dexamethasone for Chronic Subdural Hematoma' New England Journal of Medicine 383, (27) 2616-2627 Publisher Site , DOI Open access
Key publications are highlighted
Journals
Articles
(2024) 'A randomised, double blind, placebo-controlled trial of a two-week course of dexamethasone for adult patients with a symptomatic Chronic Subdural Haematoma (Dex-CSDH trial)' Health Technology Assessment 1-122 Publisher Site , DOI
(2023) 'Protocol for the development of a multidisciplinary clinical practice guideline for the care of patients with chronic subdural haematoma' Wellcome Open Research 8, 390-390 Publisher Site , DOI
(2023) 'Systematic review on traumatic intracranial haemorrhage in patients on anti-thrombotic medications; haemorrhage progression, thrombosis, and anti-thrombotic recommencement' Neurosurgical Review 46, (1) Publisher Site , DOI
(2023) 'How does research activity align with research need in chronic subdural haematoma: a gap analysis of systematic reviews with end-user selected knowledge gaps' Acta Neurochirurgica Publisher Site , DOI
(2023) 'Is information provided within chronic subdural haematoma education resources adequate? A scoping review' PLOS ONE 18, (4) e0283958-e0283958 , DOI Open access
(2023) 'Machine learning driven prediction of cerebrospinal fluid rhinorrhoea following endonasal skull base surgery: A multicentre prospective observational study' Frontiers in Oncology 13, , DOI Open access
(2023) 'CSF rhinorrhoea after endonasal intervention to the skull base (CRANIAL): A multicentre prospective observational study' Frontiers in Oncology 12, , DOI Open access
(2022) 'Presentation, management, and outcomes of cauda equina syndrome up to one year after surgery, using clinician and participant reporting: a multi-centre prospective cohort study' The Lancet Regional Health - Europe 24, 100545-100545 , DOI Open access
(2022) 'Could a Medication Help With Bleeding Between the Skull and the Brain?' Frontiers for Young Minds 10, , DOI Open access
(2022) 'Dexamethasone reduces vascular endothelial growth factor in comparison to placebo in post-operative chronic subdural hematoma samples: A target for future drug therapy?' Frontiers in Neurology 13, , DOI Open access
(2022) 'A systematic review identifying outcome measures used in evaluating adults sustaining cervical spine fractures' European Spine Journal , DOI Open access
(2022) 'Duration of External Neck Stabilisation (DENS) following odontoid fracture in older or frail adults: protocol for a randomised controlled trial of collar versus no collar' BMJ Open 12, (7) , DOI Open access
(2022) 'Delivering Large-Scale Neurosurgical Studies in the UK: The Impact of Trainees' World Neurosurgery 161, 343-349 , DOI Open access
(2022) 'Challenges and opportunities in the care of chronic subdural haematoma: perspectives from a multi-disciplinary working group on the need for change' British Journal of Neurosurgery 1-9 , DOI Open access
(2021) 'Integrated care pathways in neurosurgery: A systematic review' PLOS ONE 16, (8) , DOI Open access
(2021) 'Study Protocol on Defining Core Outcomes and Data Elements in Chronic Subdural Haematoma' Neurosurgery 89, (4) 720-725 , DOI Open access
(2021) 'First Report of a Multicenter Prospective Registry of Cranioplasty in the United Kingdom and Ireland' Neurosurgery 89, (3) 518-526 Publisher Site , DOI Open access
(2021) 'Pathogenesis of Chronic Subdural Hematoma: A Cohort Evidencing De Novo and Transformational Origins' Journal of Neurotrauma 38, (18) 2580-2589 Publisher Site , DOI Open access
(2021) 'Balancing risks and benefits when recommencing oral anticoagulants after major bleeding' Thrombosis and Haemostasis Publisher Site , DOI Open access
(2021) 'The gender gap in European neurosurgical conference presentations' Neurosurgical Focus 50, (3) , DOI Open access
(2020) 'Trial of Dexamethasone for Chronic Subdural Hematoma' New England Journal of Medicine 383, (27) 2616-2627 Publisher Site , DOI Open access
(2020) 'The changing face of neurosurgery for the older person' Journal of Neurology 267, (8) 2469-2474 Publisher Site , DOI Open access
(2020) 'Systematic review of current randomised control trials in chronic subdural haematoma and proposal for an international collaborative approach' Acta Neurochirurgica 162, (4) 763-776 Publisher Site , DOI Open access
(2019) 'Statistical analysis plan for the Dex-CSDH trial: a randomised, double-blind, placebo-controlled trial of a 2-week course of dexamethasone for adult patients with a symptomatic chronic subdural haematoma' Trials 20, (1) , DOI Open access
(2019) 'Management evaluation of metastasis in the brain (MEMBRAIN)—a United Kingdom and Ireland prospective, multicenter observational study' Neuro-Oncology Practice 7, (3) 344-355 Publisher Site , DOI Open access
(2019) 'Evaluation of nationwide referral pathways, investigation and treatment of suspected cauda equina syndrome in the United Kingdom' British Journal of Neurosurgery 33, (6) 624-634 , DOI Open access
(2019) 'Dex-CSDH randomised, placebo-controlled trial of dexamethasone for chronic subdural haematoma: report of the internal pilot phase' Scientific Reports 9, (1) 0-0 , DOI Open access
(2019) 'Correction to: Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial' Trials 20, (1) Publisher Site , DOI Open access
(2018) 'Dexamethasone for adult patients with a symptomatic chronic subdural haematoma (Dex-CSDH) trial: study protocol for a randomised controlled trial' Trials 19, (1) 0-0 , DOI Open access
(2017) 'Recognising contributions to work in research collaboratives: Guidelines for standardising reporting of authorship in collaborative research' International Journal of Surgery 52, 355-360 Publisher Site , DOI
(2017) 'The British Neurosurgical Trainee Research Collaborative: Five years on' Acta Neurochirurgica 160, (1) 23-28 , DOI Open access
(2017) 'The role of pharmacotherapy in the management of chronic subdural haematoma' Swiss Medical Weekly Publisher Site , DOI
(2017) 'Pathophysiology of chronic subdural haematoma: inflammation, angiogenesis and implications for pharmacotherapy' Journal of Neuroinflammation 14, (1) Publisher Site , DOI Open access
(2016) 'Core Outcomes and Common Data Elements in Chronic Subdural Hematoma: A Systematic Review of the Literature Focusing on Baseline and Peri-Operative Care Data Elements' Journal of Neurotrauma 33, (17) 1569-1575 , DOI Open access
Chapters
(2021) 'Non-functioning Pituitary Adenoma' Rhinology and Anterior Skull Base Surgery Springer International Publishing 161-168 Publisher Site , DOI
(2020) 'Neurosurgical Complications of Head Injury' Traumatic Brain Injury Cambridge University Press 247-257 Publisher Site , DOI
(2017) 'Chronic Subdural Haematoma in the Elderly' Brain and Spine Surgery in the Elderly Springer International Publishing 353-371 Publisher Site , DOI
Conference Papers
(2019) 'TP1-3 Final phase of recruitment and statistics analysis plan for Dex-CSDH trial' BMJ e10.4-e11 Publisher Site , DOI
(2016) 'A RANDOMISED, DOUBLE BLIND, PLACEBO-CONTROLLED TRIAL OF A TWO-WEEK COURSE OF DEXAMETHASONE FOR ADULT PATIENTS WITH A SYMPTOMATIC CHRONIC SUBDURAL HAEMATOMA (DEX-CSDH TRIAL)' A15-A16
(2016) 'CORE OUTCOMES AND COMMON DATA ELEMENTS IN CHRONIC SUBDURAL HAEMATOMA (CODE-CSDH)' A15-A15
Presentations and posters
'The UK Cranioplasty Study and Development of the UK Cranial Reconstruction Registry' , DOI
Other Publications
(2021) Letter to the Editor. A UK perspective on gender diversity in American neurosurgery training programs. Journal of Neurosurgery Publishing Group (JNSPG) Publisher Site , DOI Open access
Personal
Personal
Additional information
In addition to my passion for neurosurgery, I am a mother and a passionate advocate for the role of women in neurosurgery and academia. I have been invited to be part of an equality and diversity task force led by the EANS to help improve recruitment and working standards for diverse groups within neurosurgery. I think the establishment and availability of good role models in the field is essential and am always happy to be contact by students or colleagues with similar interests.