Peninsula Clinical Trials Unit: Study Portfolio

Title: A novel way to understand and communicate the burden of Antipsychotic Prescribing for Adults across Specialist Intellectual Disability Services in England and Wales.

Chief Investigator: Professor Rohit Shankar , Faculty of Health, University of Plymouth

Title: Β-hydroxy β-methylbutyrate (HMB) supplementation to optimise outcomes in advanced liver cirrhosis: a multicentre double blind placebo controlled
randomised trial.

Chief Investigator: Dr Ashwin Dhanda , Faculty of Health, University of Plymouth

Title: Personalised social and self-management support for better living with multiple long-term conditions in the community.

Chief Investigator: Dr Dorit Kunkel, University of Southampton

Title: Empowered Together: A feasibility and definitive randomised controlled trial, with embedded realised informed process evaluation.

Chief Investigator: Dr Katrina Forsyth, University of Manchester

Title: A feasibility randomised controlled trial, of administering daytime only enteral feeding compared to standard continuous enteral feeding, to reduce delirium in mechanically ventilated, critically ill adults.

Chief Investigator: Dr Jessie Welbourne , University Hospitals Plymouth NHS Trust

Title: D-PACT: Dementia PersonAlised Care Team

Chief Investigator: Professor Richard Byng , Faculty of Health, University of Plymouth

Title: Realist informed mixed methods evaluation of the Dementia-Personalised Aligned Care Team intervention (D-PACT): a complex intervention for individuals with dementia and carers.

Chief Investigator: Professor Richard Byng , Faculty of Health, University of Plymouth

Title: Randomised, Phase II open label study of Rituximab/Ibritinib vs Rituximab/Chemo in older patients with mantle cell lymphoma.

Chief Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust

CRUK ISRCTN11038174

Title: Evaluating the efficacy of Remdesivir for the improvement of lung function, perfusion, and symptom profile in long-covid patients.

Chief Investigator: Dr Mark Faghy, University of Derby

Title: Does in-bed Cycling delivered within 48 hours of mechanical ventilation, rEduce the occurrence of Delirium in critically ill patients: A mixed-methods Feasibility Randomised controlled trial protocol.

Chief Investigator: Jacqueline Bennion

Title: Establishing a biobank and database as a national resource for characterising indolent and aggressive forms of mantle cell lymphoma.

Chief Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust

CRUK / Janssen Pharmaceuticals

Title: A randomized phase II trial evaluating Ibrutinib plus CD20 Ab and Ibrutinib-Venetoclax plus CD20 Ab in patients with untreated mantle cell lymphoma.

Chief Investigator: Professor Steven Le Gouill, Institut Curie – Paris

Associate Coordinating Investigator: Dr David Lewis, University Hospitals Plymouth NHS Trust

Title: How are treatment outcomes for people with severe obesity ImPROved by GROUP-based behavioural intervention?

Chief Investigator: Professor Jonathan Pinkney , Faculty of Health, University of Plymouth

Press release

Title: RAtionalising Psychotropic medications for adults with Intellectual Disabilities: sCOPing

Chief Investigator: Professor Shoumitro Deb, Imperial College London

Title: Older people with intellectual disabilities and epilepsy – recognising and correcting anticholinergic inducing polypharmacy

Chief Investigator: Professor Rohit Shankar , Faculty of Health, University of Plymouth

Title: Neuropsychiatric Research Register for people with Intellectual Disabilities and Epilepsy

Chief Investigator: Professor Rohit Shankar , Faculty of Health, University of Plymouth

Title: nutRition intervEntions For malnouRished oldEr adultS in care Homes: a parallel, superiority, three-arm cluster randomised controlled trial.

Chief Investigator: Professor Mary Hickson , Faculty of Health, University of Plymouth

Title: Reducing SteatOsis Prior to Liver Resection – A feasibility multi-centre randomised controlled trial to test if a pre-operative two-week very low-calorie diet with dietitian education and support reduces intra-operative blood loss and improves post-operative outcomes following liver surgery, compared with a control group

Chief Investigator: Mr Somaiah Aroori , Faculty of Health, University of Plymouth

Title: Repurposing anti-retroviral drugs to treat NF2 related tumours

Chief Investigator: Professor Oliver Hanemann , Faculty of Health, University of Plymouth

Title: The Efficacy of Peroneal Nerve Functional Electrical STimulation (FES) for the Reduction of Bradykinesia in Parkinson’s DiSease: An Assessor Blinded Randomised Controlled Trial

Chief Investigator: Professor Paul Taylor, Salisbury NHS Foundation Trust

Title: The South West Impact of Multiple Sclerosis (SWIMS) project – a patient-orientated longitudinal study of the impact of multiple sclerosis in South West England.

Chief Investigator: Professor Jeremy Hobart , Faculty of Health, University of Plymouth