Genetic toxicology and ecotoxicology publications

1. Co-Edited Special issue of Marine Pollution Bulletin, The English Channel and it’s catchments: Status and Responses to Contaminants’. Vol 95, 2015.

2. Managing and Special Issue editor, Journal of Environmental Radioactivity; Environmental Radioactivity: Implications of Human and Environmental Health, Vol 133, 2014.

Review Articles (since 2014)

Collins AR et al. (79 authors: ANJ: 34 position) (2023) Measuring DNA damage with the comet assay: a compendium of protocols. Nature Protocol. https://www.nature.com/articles/s41596-022-00754-y

TS Kumaravel, TN Sathya, R Balaje, P Pradeepa, D Yogaraj, MR Murali, KR Navaneeth krishnan, S Murugan, AN Jha (2022) Genotoxicity evaluation of medical devices: A regulatory perspective. Mutation Research-Reviews in Mutation Research 789, 108407.

Mothersill CE, DH Oughton, PN Schofield, M Abend, K Ariyoshi, NA Beresford, A Bonisoli-Alquati, J Cohen, Y Dubrova, SA Geras’kin, TH Hevrøy, KA Higley, N Horemans, AN Jha, LA Kapustka, JG Kiang, BG Madas, G Powathil, EI Sarapultseva, CB Seymour, NTK Vo, MD Wood (2022) From tangled banks to toxic bunnies; a reflection on the issues involved in developing an Ecosystem approach for environmental radiation protection. International Journal of Radiation Biology 98, 6, 1185–1200.

Beresford NA N Horemans, D Copplestone, KE Raines, G Orizaola, MD Wood, P Laanen, P Laanen, HC Whitehead, JE Burrows, MC Tinsley, JT Smith, J-M Bonzom, B Gagnaire, C Adam-Guillermin, S Gashchak, AN Jha, A de Menezes, N Willey, D Spurgeon (2020) Towards solving a scientific controversy – The effects of ionising radiation on the environment. Journal of Environmental Radioactivity 211, article no106033, 1-8.

Mussttaf RA, DF Jenkins, AN Jha (2019) Assessing the Impact of Low Level Laser Therapy (LLLT) on Biological Systems: A Review. International Journal of Radiation Biology 95, 2, 120-143.

Jha AN (2018) Professor Adayapalam Tyagarajan Natarajan (1928-2017): a tribute (obituary). Mutagenesis 32, 545-546.

Al-Sarawi, HA, AN Jha, MA Al-Sarawi, BP Lyons (2015) Historic and contemporary contamination in the marine environment of Kuwait: an overview. Marine Pollution Bulletin 100, 621–628.

Millward GE, AN Jha, C Minier, N. Pope, WJ Langston (2015) The English Channel and its catchments: Status and responses to contaminants. Marine Pollution Bulletin 95, 523-528.

Dallas LJ and AN Jha (2015) Applications of biological tools or biomarkers in aquatic biota: a case study of the Tamar estuary, South West England. Marine Pollution Bulletin 95, 618-633.

Wang Q, AN Jha, X Chen, J-f Dong, X-min Wang (2015) The future of nuclear safety: vital role of geoscientists? Renewable and Sustainable Energy Review 43, 239-243.

Jha AN, WH Blake, GE Millward (2014) Environmental Radioactivity: implications for human and environmental health. Journal of Environ. Radioactivity 133, 1-4.

Werschkun B, S Banerji, OC Basurko, M David, F Fuhr, S Gollasch, T Grummt, M Haarich, AN Jha, S Kacan, A Kehrer, J Linders, E Mesbahi, D Pughiuc, SD Richardson, B Schwarz-Schulzj, A Shah, N Theobald, U von Gunten, S Wieck, T Höfer, (2014) Emerging risks from ballast water treatment: The run-up to the International Ballast Water Management Convention. Chemosphere 112, 256-266.

Wang Q, Xi Chen, AN Jha, H Rogers (2014) Natural Gas from Shale Formation – The Evolution, Evidences and Challenges of Shale Gas Revolution in United States. Renewable and Sustainable Energy Review 30, 1-28.

Original Scientific Papers (since 2014)

Mentana A, Y Lamartinière, T Orsière, V Malard, M Payet, D Slomberg, I Guardamagna, L Lonati, C Grisolia, A Jha, L Lebaron-Jacobs, J Rose, A Ottolenghi, G Baiocco (2023) Tritiated Steel Micro-Particles: Computational Dosimetry and Prediction of Radiation-Induced DNA Damage for In Vitro Cell Culture Exposures. Radiation Research (in press) https://doi.org/10.1667/RADE-22-00043.1

Vernon EL, AN Jha, MF Ferreira, DL Slomberg, V Malard, C Grisolia, M Payet, A Turner (2022) Bioaccumulation, release and genotoxicity of stainless steel particles in marine bivalve molluscs. Chemosphere 303, 134914.

Vernon EL, MN Moore, TP Bean, AN Jha (2022) Evaluation of interactive effects of phosphorus-32 and copper on marine and freshwater bivalve molluscs. International Journal of Radiation Biology 98, 6, 1106–1119.

Kumaravel TS, B Brabu, N Parthiban, SS Murugan, AN Jha (2021) ‘Site of contact genotoxicity’ assessment for implants - potential use of single cell gel electrophoresis in biocompatibility testing of medical devices. Toxicology Letters 341, 59–67.

Baiocco G, I George, S Garcia-Argote, I Guardamagna, L Lonati, Y Lamartinière, T Orsière, B Rousseau, A Ottolenghi, A Jha, L Lebaron-Jacobs, C Grisolia and Véronique Malard (2021) A 3D in vitro model of the human airway epithelium exposed to tritiated water: dosimetric estimate and cytotoxic effects. Radiation Research 195 (3): 265–274.

Moore MN, S Sforzini, A Viarengo, A Barranger, Y Aminot, JW Readman, AN Khlobystov, VM Arlt, M Banni, AN Jha (2021) Antagonistic cytoprotective effects of C60 fullerene nanoparticles in simultaneous exposure to benzo[a]pyrene in a molluscan animal model. The Science of the Total Environment 755, 142355.

Alnajar N, AN Jha, A Turner (2021) Impacts of microplastic fibres on the marine mussel, Mytilus galloprovincialis. Chemosphere 262, 128290.

Sforzini S, C Oliveri, A Barranger, AN Jha, M Banni, MN Moore, A Viarengo (2020) Effects of fullerene C60 in blue mussels: Role of mTOR in autophagy related cellular/tissue alterations. Chemosphere 246, 125707.

Vernon EL, TP Bean, AN Jha (2020) Assessing relative biomarker responses in marine and freshwater bivalve molluscs following exposure to phosphorus 32 (32P): Application of genotoxicological and molecular biomarkers. Journal of Environmental Radioactivity 213, 106120.

Barranger A, GA Rance, Y Aminot, LJ Dallas, S Sforzini, NJ Weston, RW Lodge, M Banni, VM Arlt, MN Moore, JW Readman, A Viarengo, AN Khlobystov, AN Jha (2019) An integrated approach to determine interactive genotoxic and global gene expression effects of multiwalled carbon nanotubes (MWCNTs) and Benzo[a]pyrene (BaP) on marine mussels: Evidence of reverse ‘Trojan Horse’ effects. Nanotoxicology 13, 1324-1343.

Barranger A, LM Langan, V Sharma, GA Rance, Y Aminot, NJ Weston, F Akcha, MN Moore, VM Arlt, AN Khlobystov, JW Readman, AN Jha (2019) Antagonistic Interactions between Benzo[a]pyrene and Fullerene (C60) in Toxicological Response of Marine Mussels. Nanomaterials 9, 987. doi:10.3390/nano9070987.

Olmastroni S, G Pompeo, AN Jha, E Mori, ML Vannuccini, Niccolò Fattorini, Nicoletta Ademollo, I Corsi (2019) Erythrocytes nuclear abnormalities and leukocyte profile of the immune system of Adélie penguins (Pygoscelis adeliae) breeding at Edmonson Point, Ross Sea. Polar Biology 42, 1343-1352.

Vernon EL, AN Jha (2019) Assessing relative sensitivities of marine and freshwater bivalves following exposure to copper: Application of classical and novel genotoxicological biomarkers. Mutation Research 842, 60-71.

Langan LM,, SF Owen, M Trznadel, NJF Dodd, SK Jackson,WM. Purcell, AN Jha (2018) Spheroid size does not impact metabolism of the β-blocker propranolol in 3D intestinal fish model. Frontiers in Pharmacology 9, Article 947; doi:103389/phar2018.00947.

Vernon EL, JT Smith, AN Jha (2018) Relative comparison of tissue specific bioaccumulation and radiation dose estimation in marine and freshwater bivalve molluscs following exposure to phosphorus 32. Journal of Environmental Radioactivity 192, 312-320.

Langan LM, SF Owen, AN Jha (2018b) Establishment and long term maintenance of primary intestinal epithelial cells cultured from the rainbow trout, Oncorhynchus mykiss. BIOLOGY OPEN, bio032870. doi:10.1242/bio.032870.(Open access; Cover Page Article).

Langan LM, S Arossa, SF Owen, AN Jha (2018a) Assessing the impact of benzo[a]pyrene with the in vitro fish gut model: An integrated approach for eco-genotoxicological studies. Mutation Research(Genetic Toxicology & Environmental Mutagenesis), 826, 53–64.

Pearson HBC, LJ Dallas, SDW Comber, CB Braungardt, PJ Worsfold, AN Jha (2018) Mixtures of tritiated water, zinc and dissolved organic carbon: Assessing interactive bioaccumulation and genotoxic effects in marine mussels, Mytilus galloprovincialis. Journal of Environmental Radioactivity 187, 133-143.

Mussttaf RA, D Jenkins, A Jha (2018) Photo-stimulatory effect of LLLT on the proliferation rate of human monocytic leukaemia cells. IET-Nanobiotechnology 12, 175-181.

Sforzini S, C Oliveri, A Orrù, G Chessa, B Pacchioni, C Millino, AN Jha, A Viarengo, M Banni (2018b) Application of a new targeted low density microarray and conventional biomarkers to evaluate the health status of marine mussels: A field study in Sardinian coast, Italy. The Science of the Total Environment 628–629, 319–328.

Sforzini S, MN Moore, C Oliveri, A Volta, A Jha, M Banni, A Viarengo (2018a) Role of mTOR in autophagic and lysosomal reactions to environmental stressors in molluscs. Aquatic Toxicology 195, 114–128.

Dallas LJ, A Turner, TP Bean, BP Lyons, AN Jha (2018) An integrated approach to assess the impacts of zinc pyrithione at different levels of biological organization in marine mussels. Chemosphere 196, 531-539.

Sanchis J, Y Aminot, E Abad, AN Jha, JW Readman, M Farre (2018) Transformation of C60 fullerenes aggregates suspended and weathered under realistic environmental conditions. Carbon 128, 54-62.

Al-Sarawi HA, AN Jha, C Baker-Austin, MA Al-Sarawi, BP Lyons (2018) Baseline screening for the presence of antimicrobial resistance in E. coli isolated from Kuwait’s marine environment. Marine Pollution Bulletin 129, 893-898.

Maunder RJ, MG Baron, SF Owen, AN Jha (2017) Investigations to extend viability of a rainbow trout primary gill cell culture. Ecotoxicology 26,1314-1326.

Langan LM, GM Harper, SF Owen, WM Purcell, SK Jackson, AN Jha (2017) Application of the rainbow trout derived intestinal cell line (RTgutGC) for ecotoxicological studies: molecular and cellular responses following exposure to copper. Ecotoxicology 26, 1117-1133 (Open Access).

Banni M, S Sforzini, VM Arlt, A Barranger, LJ Dallas, C Oliveri, Y Aminot, B Pacchioni, C Millino, G Lanfranchi, JW Readman, MN Moore, A Viarengo, AN Jha (2017) Assessing the impact of Benzo[a]pyrene on Marine Mussels: application of a novel targeted low density microarray complementing classical biomarker responses. PLoS ONE 12 (6): e0178460doi.org/10.1371/journl.pone.0178460.

Baron MG, KS Mintram, SF Owen, MJ Hetheridge, A John Moody, WM Purcell, SK Jackson, AN Jha (2017) Pharmaceutical metabolism in fish: using a 3-D hepatic in vitro model to assess clearance. PLoS ONE 12(1): e0168837.doi:10.1371/journal.pone.0168837.

Di Y, Y Aminot, DC Schroeder, JW Readman, AN Jha (2017) Integrated biological responses and tissue-specific expression of p53 and ras genes in marine mussels following exposure to benzo(α)pyrene and C60 fullerenes, either alone or in combination. Mutagenesis 32, 77-90.

Oommen D, NJF Dodd, D Yiannakis, R Moyeed, AN Jha (2016) Linking genotoxicity and cytotoxicity with membrane fluidity: a comparative study in ovarian cancer cell lines following exposure to auranofin. Mutation Research- Genetic Toxicology and Environmental Mutagenesis 809, 43-49.

Oommen D, D Yiannakis, AN Jha (2016) BRCA1 deficiency increases the sensitivity of ovarian cancer cells to auranofin. Mutation Research 784 (Fundamental Mol. Mech. of Mutagenesis), 8–15.

Dallas LJ, TP Bean, A Turner, BP Lyons, AN Jha (2016) Exposure to tritiated water at an elevated temperature: genotoxic and transcriptomic effects in marine mussels (M. galloprovincialis). Journal of Environmental Radioactivity 164, 325-336.

Dallas LJ, A Devos, B Fievet, A Turner, BP Lyons, AN Jha (2016) Radiation dose estimation for marine mussels following exposure to tritium: best practice for use of the ERICA tool in ecotoxicological studies. Journal of Environmental Radioactivity 155-156, 1-6.

Dissanayake A, AG Scarlett, AN Jha (2016) Diamondoid naphthenic acids cause in vivo genetic damage in gills and haemocytes of marine mussels. Environmental Science and Pollution Research 23, 7060-7066.

Langan LM, NJF Dodd, SF Owen, WM Purcell, SK Jackson, AN Jha (2016) Direct measurements of oxygen in the middle of 3D tissue cultures using electron paramagnetic resonance spectroscopy. PLoS ONE DOI:10.1371/journal.pone.0149492.

Barón E, A Dissanayake, V Judit, C Crowther, J Readman, A Jha, E Eljarrat, D Barcelo (2016) Evaluation of the genotoxic and physiological effects of decabromodiphenyl ether (BDE-209) and dechlorane plus (DP) flame retardants in marine mussels (Mytilus galloprovincialis). Environmental Science and Technology 50, 2700-2708.

Devos A, LJ Dallas, C Voiseux, C Lecomte-Pradines, AN Jha, B Fievet (2015) Assessment of growth, genotoxic responses and expression of stress related genes in the Pacific oyster Crassostrea gigas following chronic exposure to ionizing radiation. Marine Pollution Bulletin 95, 688-698.

Mustafa SA, SS Karieb, SJ Davies, AN Jha (2015) Assessment of oxidative damage to DNA, transcriptional expression of key genes, lipid peroxidation and histopathological changes in carp Cyprinus carpio L. following exposure to chronic hypoxic and subsequent recovery in normoxic conditions. Mutagenesis 30, 107-116.

D’Agata A, S Fasulo, LJ Dallas, AS Fisher, M Maisano, JW Readman, AN Jha (2014) Enhanced toxicity of ‘bulk’ titanium dioxide compared to ‘fresh’ and ‘aged’ nano-TiO2 in marine mussels (Mytilus galloprovincialis). Nanotoxicology 8, 549-558.

S A. Mustafa & A N. Jha (2022) The impact of hypoxia and dead zones on marine habitat destruction and fish populations. In. Dynamics and Interrelations between nature, Science and Society. Chapter 6, pp. 147-167. Eds. KK Jha and M Campbell. Nova Science Publishers. doi.org/10.52305/MRZG7075; ISBN: 979-8-88697-053-1.

DFL Jenkins, JM Bloor, B Li, VS Raghaven, RD Handy, SH Puttaiah, AN Jha, SS Gorthi (2022) Nanomaterials and devices for the provision of safe drinking water in rural communities. (Chapter 16; pp 378-402). In Contaminants of Emerging Concerns and Reigning Removal Technologies (Eds. M Kumar, S Mohapatra and K Acharya); CRC Press; doi.org/10.1201/9781003247869; eBook ISBN9781003247869.

Farre M and AN Jha (2020) Metabolomics effects of nanomaterials: an ecotoxicological perspective. In Environmental Metabolomics: Applications in the field and laboratory studies from the exposure to the metabolome (Chapter 9; pp 259-81). (Eds. Diana Alvarez-Munoz and Marinella Farre). Elsevier. ISBN: 97801281966.

Refereed Conference Proceedings (since 2014)
(Abstracts in Peer-Reviewed International Journals)

Jha AN (2022) An integrated approach to assess the impact of emerging contaminants on aquatic organisms. Environmental & Molecular Mutagenesis 63, 43-43.

Oommen D, N Dodd , D Yiannakis, A Jha (2016) Auranofin-induced genotoxicity and cytotoxicity positively correlates with membrane fluidity: a comparative study in ovarian cancer cell lines. Mutagenesis 31, 719.

Mussttaf RA , A Jha, D Jenkins (2016) Fluence of low level laser therapy affects proliferation and DNA damage in THP-1 cells. Mutagenesis31, 725-726.

Dallas LJ, VM Arlt , S Sforzini , M Banni , Y Animot , JW Readman , A Viarengo, AN Jha (2016)Tissue-specific differences in transcriptomic and genotoxic responses of marine mussels exposed to benzo[a] pyrene. Mutagenesis 31, 732.

Jha AN (2015) Modified comet assay to determine oxidative damage to DNA in aquatic organisms: role of confounding factors influencing the results. Front. Genet. ICAW 2015 - 11th International Comet Assay Workshop. doi: 10.3389/conf.fgene.2015.01.00022.

Maynard R, Parkinson D and Jha AN (2015) Comparing the alkaline comet with 53BP1 immunocytochemistry assay: sensitivity and cost/time effectiveness. Front. Genet. ICAW 2015 - 11th International Comet Assay Workshop. doi: 10.3389/conf.fgene.2015.01.00008

Dallas L, C Oliveri, M Banni, Y Aminot, V Arlt, S Sforzini, JW Readman, A Viarengo, AN Jha (2015) Novel insights into benzo(a)pyrene toxicity in marine mussels: an integrated approach incorporating a new targeted low density microarray. Mutagenesis 30, 852.

Oommen D, N Dodd, D Yiannakis, AN Jha (2015) Modulation of drug sensitivity by genetic and biophysical determinants: role of BRCA1 and membrane fluidity in regulating the sensitivity of ovarian cancer cells to potential anti-cancer drug, auranofin. Mutagenesis 30, 853.

Langan LM, SF Owen, SK Jackson, WM Purcell, AN Jha (2015) Can a cell line behave like native tissue in 3-dimensional form? A case study using RTgutGC as a model for copper uptake and metabolism. Mutagenesis 30, 857.

Baron M, K Mintram, S Owen, C Dummett, T Henry, J Moody, W Purcell, S Jackson, A Jha (2015) Cell to fish: replacing animals in aquatic ecotoxicology. Mutagenesis 30, 864.

Di Y, SN Al-Subiai, LJ Dallas, VM Arlt, JW Readman, B Stolpe, JR Lead, D Schorder, AJ Moody, AN Jha (2015) Interaction of engineered nanoparticles with PAHs: could they act as “Trojan-horses” to induce biological responses in marine species? Mutagenesis 30, 865-866.

Langan L, Nicholas Dodd, SF Owen, SK Jackson, WM Purcell, AN Jha (2015) Fish cell lines in 3-dimensional (3D) cultures in ecotoxicological studies: is there oxygen in the middle? Mutagenesis 30, 874-875.

Vicari T, M Baron, R Maunder,A La Torre, G Rance, A Khlobystov, A Jha (2015) Uptake, distribution and toxicological effects of two different silver nanomaterials in 3-D in vitro fish cultures. Mutagenesis 30, 875.

Maynard R, DB Parkinson, AN Jha (2015) Differential sensitivity of differentiated and undifferentiated dopaminergic neuronal SH-SY5Y cells following exposure to copper. Mutagenesis 30, 875.

Mussttaf R, D Jenkins, A Jha (2015) Assessing the impact of low level laser therapy on biological systems: a review. Mutagenesis 30, 875-876.

D Oommen, N Dodd, D Yiannakis, A Jha (2014) Auranofin induced genotoxicity and cytotoxicity correlates with membrane fluidity in ovarian cancer cells. Mutagenesis 29, 526.

Jha AN (2014) Applications of biomarkers in aquatic organisms: linking human and environmental health. Mutagenesis 29, 537.

Langan L, N Dodd , S F Owen, SK Jackson, WM Purcell, AN Jha (2014) Fish cell lines in 3 dimensional (3D) cultures in ecotoxicological studies: is there oxygen in the middle? Mutagenesis 29, 539-40.

Dallas LJ, Y Di , TP Bean , BP Lyons , A Turner, AN Jha (2014) Adverse outcome pathways for metal and radionuclide exposure: an ecotoxicological perspective using mussels as a sentinel organism. Mutagenesis 29, 541.