Cell and tissue surfaces are crucial in the regulation normal body function. They control the passage of a variety of substances and physically separate parts of the cell and tissues which have different functions. As with many crucial processes these borders are disrupted in disease and can represent a crucial ‘battleground’ which determines outcome but also represents diagnostic and therapeutic opportunities.
In his inaugural lecture, Simon will use examples from pathological science to highlight how the cell surface can catalyse enzyme reactions and how dysfunction of this system can lead to tissue surfaces sticking together in the abdominal cavity forming peritoneal adhesions which are a leading cause of small bowel obstruction and secondary infertility in women.
Simon’s recent work has highlighted the crucial role of what was previously thought to be relatively normal tissue or stroma surrounding tumours including those originating from the oral cavity. By reflecting the progress of the ‘battle’, cells within this border may be better diagnostic markers of disease than features of the tumour itself and represent an area where specific interventions may represent a promising therapeutic target.
When you are on the border, you can see both ways
There will be an opportunity for Simon to answer your questions at the end of his lecture.
You are welcome to join us for University of Plymouth's Inaugural Professorial Lecture series, which provide a milestone event in a professorial career. Through these we can promote and celebrate the academic reputation and achievements within their research.
This hybrid-delivery event is open to the public and free to attend, booking is required